Research Article
The Polymorphism in ADORA3 Decreases Transcriptional Activity and Influences the Chronic Heart Failure Risk in the Chinese
Table 2
Genotype distribution of the rs1544223 and its associations with the risk of chronic heart failure under different contrast models.
| | Genotype | CHF
(%) | Controls
(%) | HWE
| Dominant model
; , OR (95% CI) | Recessive model
; , OR (95% CI) | Additive model
; , OR (95% CI) | Allele contrast
; , OR (95% CI) |
| | rs1544223 | | | | | | | | | (Xi’an) | | | | | | | | | GG (W) | 30 (10.03) | 63 (15.83) | 0.0732 | 0.0259; 0.046, | 0.2415; 0.207, | 0.0764; 0.059, | 0.0471; 0.055, | | AG | 131 (43.81) | 169 (42.46) | | 1.662 | 1.233 | 1.256 | 1.265 | | AA | 138 (46.15) | 166 (41.71) | | (1.009–2.738) | (0.890–1.708) | (0.991–1.593) | (0.995–1.608) |
| | rs1544223 | | | | | | | | | (Kunming) | | | | | | | | | GG | 25 (9.21) | 58 (14.43) | 0.0510 | 0.011; 0.048, | 0.017; 0.075, | 0.011; 0.025, | 0.002; 0.02, | | AG | 116 (37.83) | 165 (41.04) | | 1.689 | 1.338 | 1.31 | 1.336 | | AA | 163 (52.96) | 179 (44.53) | | (1.004–2.841) | (0.971–1.843) | (1.034–1.661) | (1.046–1.706) |
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CHF: chronic heart failure; HWE: Hardy-Weinberg equilibrium; values were calculated from two-sided -test. for age, sex, and cardiovascular risk factors (hypertension, dyslipidemia, diabetes, and smoking habit). |
