The Polymorphism in ADORA3 Decreases Transcriptional Activity and Influences the Chronic Heart Failure Risk in the Chinese
Table 3
Rs1544223 polymorphism genotype distribution and allele frequency according to NYHA and subsets of CHF patients.
Genotype
NYHA
Hypertension
Dyslipidemia
Diabetes
Smoking habit
II
III
IV
rs1544223 (Xi’an)
GG
12 (12.77%)
10 (8.55%)
8 (9.09%)
15 (8.77%)
8 (9.64%)
12 (11.54%)
10 (10.99%)
AG
43 (45.74%)
50 (42.74%)
38 (43.18%)
84 (49.12%)
32 (38.55%)
41 (39.42%)
41 (45.05%)
AA
39 (41.49%)
57 (48.72%)
42 (47.73%)
72 (42.11%)
43 (51.81%)
51 (49.04%)
40 (43.96%)
Allele frequency
0.4163
0.3982
0.3255
0.7916
0.5844
(-value)
Genotype distribution
0.7704
0.0991
0.4633
0.5095
0.8598
(-value)
rs1544223 (Kunming)
GG
5 (4.95%)
14 (11.86%)
6 (7.06%)
11 (6.47%)
4 (5.71%)
5 (4.95%)
5 (5.49%)
AG
36 (35.64%)
45 (38.14%)
35 (41.18%)
64 (37.65%)
24 (34.29%)
38 (37.62%)
37 (40.66%)
AA
60 (59.41%)
59 (50%)
44 (51.76%)
95 (55.88%)
42 (60%)
58 (57.43%)
49 (53.85%)
Allele frequency
0.1600
0.2105
0.1784
0.1669
0.5928
(-value)
Genotype distribution
0.3193
0.3992
0.4180
0.3026
0.4989
(-value)
NYHA: New York Heart Association class; -test -test: allele frequency and genotype distribution among the three groups; -test -test: allele frequency and genotype distribution versus controls.
