Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet

Figure 2

Vildagliptin reduced hepatic lipid deposition. (a) Weights of the mice in the three groups during the experiment ( per group). (b) Liver tissue stained with H&E (upper panel, magnification ×400); liver tissue sections stained with Oil Red O (lower panel, magnification ×200). (c) Liver wet weights were measured (–9). (d) The liver index was calculated using liver wet weight/body weight (–9). (e) The triglyceride (TG) content in the liver was measured and normalized with the protein content (–9). (f) Relative mRNA levels of genes related to the synthesis of TG and dipeptidyl peptidase-4 (DDP-4). Expression values were normalized to β-actin mRNA. Data was presented as the means ± SD; relative to the CD group; relative to the HFD group.

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