Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis

Figure 4

Protein–protein interaction (PPI) network analysis of DEPs. (a) Subnetwork analysis of DEPs for key candidate proteins identification; (b) a total of 28 key candidate proteins whose degree ⩾12 were identified in this study, and this module consisted of 28 nodes and 452 edges; (c) this module consisted of 9 special key candidate proteins with significant relation with prognosis of GBM patients, which were mainly associated with ribosome and spliceosome signaling pathway. Red nodes represented the upregulated DEPs and pink nodes represented downregulated DEPs, the size of each node was determined by the significance of value (larger size means more significant), the color of outer circle represented the numbers of degrees (the largest was 27 and the smallest was 1), and the deeper color of the edge represented a higher combined score between two nodes.

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