Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis

Table 1

List of 161 DEPs identified in the proteome analysis, including 65 upregulated proteins and 96 downregulated proteins in cytoplasma of U87 GBM cells treated with TMZ compared to the control group treated with DMSO.

DEPs	Protein name
Upregulated	CCDC25, HIST1H1E, KIF5C, SNAPIN, VAMP5, SLC33A1, GOLT1B, IL1B, PCNP, MINOS1, ZW10, UPP1, CTTN, FDXR, TOP1, RRM2B, ANXA4, PSMD10, ITGB, CKAP4, S100A13, LPP, ATP5I, TCEA1, TRG14, SLC2A1, TUBA4A, GNG12, hCG, CTSB, MYO1C, SIGMAR1, MAPK1IP1L, MGST1, SEC22B, ITGB1, P4HA2, FTH1, CSTB, ITGAV, GLRX, BAX, PRDX3, PLOD2, DNAJC3, PSAP, S100A11, LEPRE1, GALM, TMSB4X, SOD2, P4HA1, TMSB10, PATL1, TGM2, GNB2, MCFD2, CMBL, TNKS1BP1, GSN, MARCKS, S100A6, FKBP10, FHL2, HRSP12
Downregulated	SEC63, DPH5, NONO, MATR3, DDX5, KIAA1524, MYLK, NHP2L1, RPL29, RPL35, HNRNPR, HSD17B11, CCDC134, HSBP1, MSH2, ACTR1B, PITHD1, EEF1A1, SETD3, PRKDC, DHX9, ELAVL1, RPL14, MPDU1, TBC1D23, RPL21, TAGLN3, TOLLIP, TBC1D13, HLA-A, MYO5A, SACS, UCC1, SF1, ENOPH1, KATNAL2, FBXO7, PPP6C, EIF5B, IFI35, FAM213A, PSME3, RPL8, PMVK, NMD3, EFTUD2, SFPQ, HNRPA1, RPS15, VPS4B, CSNK2A2, SDCBP, PPID, GAPD, IPO9, EIF4A1, ARL1, EIF3M, RPS24, FAU, AHNAK2, HNRNPA3, SAR1A, NDUFAB1, PRSS1, CUL4B, TRIM28, MYO18A, ITGB6, SCAMP3, EIF5, BTF3, HDLBP, SYNCRIP, RPL9, KPNA2, G3BP2, MIF, RPL3, FASN, MCM7, AKR1C3, RPS23, PFDN4, SURF4, EEF1B2, RPL14, DDX39A, ANP32A, AHNAK, RPS25, ABCF2, NME2P1, NAP1L1, RRM1, DDX3X

DEPs: differentially expressed proteins.