Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts

Table 1

List of several compounds targeting CAFs metabolism.

Compound	Mechanism of action	Pathway target	Refs
Metformin	↑ Cav-1; ↓ MCT-4	Oxidative stress; Autophagy; Lactate transporter	[80, 87, 89, 90]
Quercetin	↑ Cav-1; ↓ MCT-4	Oxidative stress; Lactate transporter	[87, 89]
Chloroquine	↑ Cav-1; ↓ MCT-4	Autophagy; Lactate transporter	[82, 89]
NAC	↑ Cav-1; ↓ MCT-4	Oxidative stress; Lactate transporter	[20, 89–91]
L-NAME	↑ Cav-1	Oxidative stress; Mitochondrial activity	[87]
FX11	↓ LDH-A	Lactate production	[98, 99]
Indisulam	↓ CA IX	Microenvironment acidification	[100]
3-BP	↓ HK-2	Glycolysis	[102]
T-Lipo-3-BP	↓ HK-2	Glycolysis	[103]