Research Article
Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children
Table 2
Genotype distributions of GH-IGF axis related gene included in this study.
| Gene SNPs | Genotype | Control
| GHD
| HWE value |
| GHR | rs10044169 | AA | 161 (78.2%) | 148 (81.8%) | 0.751 | AC | 43 (20.9%) | 31 (17.1%) | | CC | 2 (1.0%) | 2 (1.1%) | rs12515480 | CC | 161 (78.2%) | 158 (87.3%) | 0.651 | CT | 43 (20.9%) | 22 | | TT | 2 (1.0%) | 1 (0.4%) | rs4410646 | AA | 113 (36.0%) | 81 (35.4%) | 0.330 | AC | 152 (48.4%) | 120 (52.4%) | | CC | 49 (15.6%) | 28 (12.2%) | rs6182 | GG | 252 (80.3%) | 189 (82.5%) | 0.884 | GT | 57 (18.2%) | 38 (16.6%) | | TT | 4 (1.3%) | 2 (0.9%) | rs6873545 | TT | 217 (69.1%) | 177 (77.3%) | 0.635 | CT | 91 (29.0%) | 46 | | CC | 6 (1.9%) | 6 (2.6%) | IGF1R | rs1976667 | AA | 115 (55.8%) | 83 (45.9%) | 0.957 | AG | 77 (37.4%) | 83 (45.9%) | | GG | 14 (6.8%) | 15 (8.3%) | rs2684788 | CC | 55 (26.7%) | 49 (27.1%) | 0.886 | CT | 96 (46.6%) | 88 (48.6%) | | TT | 55 (26.7%) | 44 (24.3%) | IGFBP3 | rs2132570 | GG | 134 (65.0%) | 121 (66.9%) | 0.351 | GT | 67 (32.5%) | 55 (30.4%) | | TT | 5 (2.4%) | 5 (2.8%) | IGFALS | rs17559 | GG | 132 (64.1%) | 113 (62.4%) | 0.931 | GA | 68 (33.0%) | 61 (33.7%) | | AA | 6 (2.9%) | 7 (3.9%) | rs3751893 | GG | 116 (56.3%) | 103 (56.9%) | 0.195 | GA | 77 (37.4%) | 58 (32.0%) | | AA | 13 (6.3%) | 20 (11.0%) |
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GHD, growth hormone deficiency; SNP, single-nucleotide polymorphism; is considered significant. |