Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children

Table 2

Genotype distributions of GH-IGF axis related gene included in this study.

Gene SNPs	Genotype	Control	GHD	HWE value
GHR
rs10044169	AA	161 (78.2%)	148 (81.8%)	0.751
	AC	43 (20.9%)	31 (17.1%)
	CC	2 (1.0%)	2 (1.1%)
rs12515480	CC	161 (78.2%)	158 (87.3%)	0.651
	CT	43 (20.9%)	22
	TT	2 (1.0%)	1 (0.4%)
rs4410646	AA	113 (36.0%)	81 (35.4%)	0.330
	AC	152 (48.4%)	120 (52.4%)
	CC	49 (15.6%)	28 (12.2%)
rs6182	GG	252 (80.3%)	189 (82.5%)	0.884
	GT	57 (18.2%)	38 (16.6%)
	TT	4 (1.3%)	2 (0.9%)
rs6873545	TT	217 (69.1%)	177 (77.3%)	0.635
	CT	91 (29.0%)	46
	CC	6 (1.9%)	6 (2.6%)
IGF1R
rs1976667	AA	115 (55.8%)	83 (45.9%)	0.957
	AG	77 (37.4%)	83 (45.9%)
	GG	14 (6.8%)	15 (8.3%)
rs2684788	CC	55 (26.7%)	49 (27.1%)	0.886
	CT	96 (46.6%)	88 (48.6%)
	TT	55 (26.7%)	44 (24.3%)
IGFBP3
rs2132570	GG	134 (65.0%)	121 (66.9%)	0.351
	GT	67 (32.5%)	55 (30.4%)
	TT	5 (2.4%)	5 (2.8%)
IGFALS
rs17559	GG	132 (64.1%)	113 (62.4%)	0.931
	GA	68 (33.0%)	61 (33.7%)
	AA	6 (2.9%)	7 (3.9%)
rs3751893	GG	116 (56.3%)	103 (56.9%)	0.195
	GA	77 (37.4%)	58 (32.0%)
	AA	13 (6.3%)	20 (11.0%)

GHD, growth hormone deficiency; SNP, single-nucleotide polymorphism; is considered significant.