The Chinese Medicinal Formulation Guzhi Zengsheng Zhitongwan Modulates Chondrocyte Structure, Dynamics, and Metabolism by Controlling Multiple Functional Proteins

Table 10

Validation of differentially expressed proteins using PRM assay (GZZSZTW versus Blank).

Protein name	Fold change	p value	Fold change	p value
	(iTRAQ)	(iTRAQ)	(PRM)	(PRM)
Keratin, type I cytoskeletal 42 (Krt42)	2.112	0.001	1.946	0.005
Keratin, type II cytoskeletal 5 (Krt5)	1.973	0.001	1.283	0.022
Keratin, type I cytoskeletal 16 (Krt16)	2.027	0.001	1.170	0.000
Matrix Gla protein (Mgp)	1.535	0.003	3.538	0.002
Pregnancy zone protein (Pzp)	2.088	0.001	1.733	0.000
60S ribosomal protein L35 (Rpl35)	1.537	0.001	1.923	0.021
40S ribosomal protein S23 (Rps23)	1.546	0.001	1.796	0.031
Craniofacial development protein 1 (Cfdp1)	1.683	0.015	1.847	0.030
Parathymosin (Ptms)	3.085	0.001	2.421	0.008
Histone H1.5 (Hist1h1b)	2.104	0.001	1.924	0.013
Methyl-CpG-binding protein 2 (Mecp2)	2.056	0.040	1.044	0.004
Histone H1.1 (Hist1h1a)	1.530	0.001	1.713	0.030