CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis

Table 2

Enrichment analysis of GO and KEGG pathway of DEGs in HCC.

Category	ID	Term	Count	-Value
BP	GO:0051301	Cell division	69	7.33E−33
BP	GO:0007062	Sister chromatid cohesion	32	1.74E−21
BP	GO:0006260	DNA replication	36	1.34E−19
BP	GO:0007067	Mitotic nuclear division	43	2.58E−18
BP	GO:0006270	DNA replication initiation	16	2.17E−14
BP	GO:0000082	G1/S transition of the mitotic cell cycle	24	2.84E−13
BP	GO:0007077	Mitotic nuclear envelope disassembly	15	9.00E−11
BP	GO:0031145	Anaphase-promoting complex-dependent catabolic process	18	8.02486E−10
BP	GO:0016925	Protein sumoylation	21	1.94799E−09
BP	GO:0000070	Mitotic sister chromatid segregation	11	3.5016E−09
CC	GO:0005654	Nucleoplasm	244	4.34338E−55
CC	GO:0005829	Cytosol	213	2.65555E−26
CC	GO:0005634	Nucleus	282	9.30863E−22
CC	GO:0005737	Cytoplasm	266	1.12033E−18
CC	GO:0016020	Membrane	143	3.98244E−17
CC	GO:0000777	Condensed chromosome kinetochore	25	2.062E−16
CC	GO:0000776	Kinetochore	24	4.34306E−16
CC	GO:0005635	Nuclear envelope	30	2.45558E−14
CC	GO:0005730	Nucleolus	68	1.1857E−11
CC	GO:0000775	Chromosome, centromeric region	17	1.72914E−11
MF	GO:0005515	Protein binding	452	1.69289E−45
MF	GO:0044822	poly(A) RNA binding	96	1.64645E−17
MF	GO:0005524	ATP binding	107	3.67235E−14
MF	GO:0003682	Chromatin binding	38	1.15215E−08
MF	GO:0019901	Protein kinase binding	37	1.32909E−08
MF	GO:0042393	Histone binding	15	5.49717E−05
MF	GO:0004674	Protein serine/threonine kinase activity	29	6.35606E−05
MF	GO:0003777	Microtubule motor activity	12	6.59963E−05
MF	GO:0051082	Unfolded protein binding	14	7.41926E−05
MF	GO:0003678	DNA helicase activity	7	0.000106899
KEGG pathway	hsa04110	Cell cycle	35	2.22E−19
KEGG pathway	hsa03030	DNA replication	15	6.16E−11
KEGG pathway	hsa00240	Pyrimidine metabolism	16	1.70E−05
KEGG pathway	hsa03013	RNA transport	21	2.97E−05
KEGG pathway	hsa04114	Oocyte meiosis	15	2.00E−04
KEGG pathway	hsa04115	p53 signaling pathway	11	4.22E−04
KEGG pathway	hsa03420	Nucleotide excision repair	9	6.48E−04
KEGG pathway	hsa03040	Spliceosome	15	0.001273995
KEGG pathway	hsa03430	Mismatch repair	6	0.002244294
KEGG pathway	hsa03022	Basal transcription factors	8	0.002420268