BioMed Research International / 2019 / Article / Tab 5 / Research Article
CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis Table 5 Relationship between selected up-regulated genes and clinical features in HCC.
CDK1 CCNB1 CDC20 B UB1 MAD2L1 MCM3 BUB1B MCM2 RFC4 Item Statistic - valueStatistic - valueStatistic - valueStatistic - valueStatistic - valueStatistic - valueStatistic - valueStatistic - valueStatistic - valueyears_to_birth (Spearman’s correlation) 340 −0.16 0.00 −0.09 0.09 −0.09 0.11 −0.09 0.09 −0.04 0.43 −0.11 0.04 −0.12 0.03 −0.10 0.07 −0.12 0.02 Tumor_purity (Spearma’s correlation) 343 −0.01 0.82 −0.02 0.70 −0.06 0.24 −0.05 0.32 −0.09 0.08 0.09 0.10 −0.01 0.85 0.02 0.76 0.00 0.99 overall_survival (Cox regression test) alive 220 0.26 0.00 0.34 0.00 0.29 0.00 0.25 0.00 0.34 0.00 0.32 0.00 0.24 0.00 0.31 0.00 0.37 0.00 dead 123 pathologic_stage (Kruskal-Wallis test) stage I 161 19.14 0.00 21.37 0.00 19.04 0.00 23.47 0.00 23.03 0.00 16.08 0.00 22.74 0.00 13.83 0.00 14.63 0.00 stage II 77 stage III 80 stage IV 3 race (Kruskal-Wallis test) american Indian or alaska native 1 13.12 0.00 15.19 0.00 14.12 0.00 7.51 0.06 1.05 0.79 20.12 0.00 10.93 0.01 17.21 0.00 21.99 0.00 asian 148 Black or arican american 15 white 169 pathology_T_stage (Kruskal-Wallis test) t1 168 17.25 0.00 20.33 0.00 19.96 0.00 23.64 0.00 24.03 0.00 14.16 0.00 19.89 0.00 12.42 0.01 11.72 0.01 t2 84 t3 75 t4 13 pathology_N_stage (Wilcox test) n0 239 0.09 0.20 −0.01 0.91 0.15 0.67 0.09 0.28 0.20 0.09 0.03 0.35 0.17 0.18 0.14 0.58 0.11 0.26 n1 3 pathology_M_stage (Wilcox test) m0 245 −0.14 0.24 −0.13 0.29 −0.17 0.26 −0.26 0.17 −0.09 0.36 −0.11 0.24 −0.37 0.10 −0.07 0.27 −0.11 0.18 m1 3 histological_type (Kruskal–Wallis test) fibrolamellar carcinoma 2 1.65 0.44 2.51 0.29 2.2 0.33 2.89 0.24 2.76 0.25 3.94 0.14 2.23 0.33 3.28 0.19 2.40 0.30 hepatocellular carcinoma 336 hepatocholang-iocarcinoma 5 radiation_therapy (Wilcox test) no 323 −0.07 0.59 0.02 0.80 0.03 0.98 −0.15 0.25 −0.01 0.54 −0.06 0.47 −0.14 0.24 −0.06 0.39 0.00 0.92 yes 9 residual_tumor (Kruskal-Wallis test) r0 303 1.58 0.45 0.96 0.62 2.04 0.36 2.64 0.27 1.77 0.41 1.59 0.45 1.83 0.40 2.46 0.29 1.02 0.60 r1 15 r2 1 ethnicity (Wilcox test) hispanic or latino 17 −0.09 0.11 −0.01 0.37 −0.11 0.24 −0.09 0.25 −0.09 0.37 −0.04 0.41 −0.13 0.28 −0.10 0.49 −0.05 0.48 not hispanic or latino 310