Diet Composition Differentially Affects Insulin Pathway Compromised and Control Flies

Figure 5

Life expectancy for flies on the different diet regimes. In (a) we show wild type (yw) curves (left) and life expectancy median values (right) in the different food regimes tested, in (b) the InR heteroallelic mutant combination curves (left) and life expectancy median values (right) in the different food regimes tested, in (c) the Dp110 heteroallelic mutant combination curves (left) and life expectancy median values (right) in the different food regimes tested, and in (d) the S6K heteroallelic mutant combination curves (left) and life expectancy median values (right) in the different food regimes tested. In (b), (c), and (d) we show in grey the A1 curve for yw flies for comparison. In (a) the A1 food regime is significantly different from B1 (); A2 is significantly different from B1 () and B2 (), and B1 and B2 () are significantly different. In (b) A1 is significantly different from B1 () and B2 (), A2 is significantly different from B2 (), and B1 is significantly different from B2 (). In (c) A2 is significantly different from B1 () and B2 (). Finally, in (d) A1 is significantly different from B1 () and A2 is significantly different from B1 () and B2 (). Significance is as follows: p< 0.1, p< 0.01, p< 0.001, and p> 0.0001. n=10 biological replicates of 10 flies each.

(a)

(b)

(c)

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