Tenascin-C Is Increased in Inflammatory Bowel Disease and Is Associated with response to Infliximab Therapy

<div>Mucosa TNC mRNA levels are associated with response to infliximab therapy in UC patients. (a) mRNA levels of TNC in control, responsive (R), and nonresponsive (NR) group; (b) rates of responsive or nonresponsive to infliximab in patients with low or high TNC expression; (c) receiver operating characteristic (ROC) curves illustrating the specificity and sensitivity in mucosa TNC levels to differentiate infliximab responsive or nonresponsive for UC. <svg height="10.7395pt" id="M10" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 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BioMed Research International

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Figure 4

Figure 4: Tenascin-C Is Increased in Inflammatory Bowel Disease and Is Associated with response to Infliximab Therapy 