Clinicopathological and Prognostic Significance of WW Domain Binding Protein 5 Expression in Papillary Thyroid Carcinoma
Table 1
Association of WBP5 expression with clinicopathological factors in 131 PTC patients.
Variables
WBP5
Low ()
High ()
Age (years)
<55
65
52
0.257
≥55
10
4
Gender
Men
18
11
0.301
Women
47
45
Histological variants
PTC
Classical variant
63
52
0.054
Follicular variant (infiltrative)
12
3
Solid variant
0
1
Bilaterality
Unilateral
53
48
0.043
Bilateral
22
8
Tumor number
Solitary
47
43
0.085
Multiple
28
13
Maximal tumor diameter
<1 (cm)
17
21
0.111
1~4 (cm)
51
33
>4 (cm)
7
2
Caspsule invasion
Absent
33
37
0.042
Present
10
4
Extracapsular
32
15
Intrathyroidal dissemination
Absent
61
50
0.211
Present
14
6
T staging
pT1
35
35
0.195
pT2
6
4
pT3
18
12
pT4
16
5
N staging
pN0/Nx
24
29
0.026
pN1a
29
20
pN1b
22
7
M staging
M0
74
54
0.797
M1
1
2
TNM staging
Ⅰ
67
54
0.562
Ⅱ
6
2
Ⅲ
1
0
Ⅳ
1
0
Total thyroidectomy
Not done
49
46
0.033
Done
26
10
Lymph node dissection
Not done
9
4
0.261
CCND only
35
34
CCND with MRND
31
18
Iodine radiotherapy
Not done
47
52
0
Done
28
4
Recurrence of disease
Absent
58
53
0.006
Present
17
3
aPTC, papillary thyroid carcinoma, bCCND, central compartment node dissection, cMRND, modified radical neck dissection, Significantly different by the χ2 test.
