Clinicopathological and Prognostic Significance of WW Domain Binding Protein 5 Expression in Papillary Thyroid Carcinoma

Table 2

Univariate and multivariate cox regression analysis of WBP5 expression with patient prognosis.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	-value	HR (95% CI)	-value
Age (years)	0.969 (0.933–1.007)	0.106
Gender	1.642 (0.631–4.272)	0.310
Histological variants	0.048 (0.000–9.588)	0.262
Bilaterality	3.834 (1.593–9.226)	0.003	2.704 (0.555–13.183)	0.218
Tumor number	1.555 (0.635–3.803)	0.334
Maximal tumor diameter	2.735 (1.214–6.161)	0.015	1.364 (0.458–4.058)	0.577
Capsule invasion	1.826 (1.121–2.975)	0.016	1.088 (0.552–2.145)	0.808
Intrathyroidal dissemination	2.020 (0.734–5.559)	0.173
TNM staging (I/II VS III/IV)	0.049 (0.000–234490.651)	0.700
Total thyroidectomy	3.580 (1.482–8.650)	0.005	0.138 (0.021–0.902)	0.039
Lymph node dissection	2.297 (1.044–5.055)	0.039	1.053 (0.469–2.362)	0.900
Iodine radiotherapy	15.265 (5.086–45.813)	≤0.001	26.947 (6.232–116.515)	≤0.001
WBP5 expression	0.221 (0.065–0.753)	0.016	0.746 (0.191–2.921)	0.674

HR : Hazard ratio. Statistical significance.