Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma

Figure 2

Immunostaining for EPO-R expression (400×magnification). a, c, e, and g negative expression of EPO-R in normal cervix, LSIL, HSIL, and CSCC, respectively; (b, d, f, and h) positive expression of EPO-R in normal cervix, LSIL, HSIL, and CSCC, respectively. As shown above, EPO-R expression is presented with moderate and diffuse staining in the cytoplasm of basal and spinous cells. By contrast, in the tissues of LSIL, HSIL, and CSCC, EPO-R expression is a strong and diffuse staining in the cytoplasm of cancer cells and atypical epithelial cells. A significantly increased immunostaining intensity from normal cervix to LSIL to HSIL and to CSCC could be also observed.