Relation between Red Cell Distribution Width and Mortality in Critically Ill Patients with Acute Respiratory Distress Syndrome

Table 1

Characteristics of the study patients according to RDW.

Characteristics	RDW,%			P value
	11.4 - 13.8	13.9 - 15.3	15.4 - 29
Clinical parameters, n (%)	124	140	140
Age, years	59.88 ± 18.52	65.48 ± 16.56	63.42 ± 16.67	0.031
Gender, n (%)				0.624
Female	60 (48.39)	65 (46.43)	73 (52.14)
Male	68 (54.84)	80 (57.14)	64 (45.71)
Ethnicity, n (%)				0.266
White	86 (69.35)	107 (76.43)	97 (69.29)
Black	10 ( 8.06)	9 ( 6.43)	18 (12.86)
Other	28 (22.58)	24 (17.14)	25 (17.86)
ICU stay, days	10.23 ± 9.85	8.98 ± 7.02	8.63 ± 9.45	0.307
SBP, mmHg	121.86 ± 18.38	119.16 ± 19.47	116.69 ± 18.44	0.085
DBP, mmHg	63.54 ± 11.33	60.51 ± 11.73	57.30 ± 11.36	<0.001
MBP, mmHg	81.90 ± 11.62	78.88 ± 12.48	75.89 ± 13.08	<0.001
Heart rate, beats/minute	88.86 ± 18.67	91.70 ± 17.23	90.77 ± 17.70	0.426
Respiratory rate, beats/minute	21.29 ± 5.21	21.42 ± 5.12	21.41 ± 4.72	0.970
Temperature, °C	37.12 ± 0.73	37.08 ± 0.70	36.86 ± 0.75	0.006
SPO %	96.95 ± 2.28	96.47 ± 2.03	96.57 ± 2.27	0.176
Comorbidities, n (%)
Coronary artery disease	14 (11.29)	29 (20.71)	24 (17.14)	0.118
Congestive heart failure	9 (7.26)	21 (15.00)	26 (18.57)	0.026
Atrial fibrillation	31 (25.00)	34 (24.29)	40 (28.57)	0.684
Stroke	19 (15.32)	16 (11.43)	11 (7.86)	0.163
AKI	0 (0.00)	11 (7.86)	26 (18.57)	<0.001
Liver disease	5 (4.03)	2 (1.43)	19 (13.57)	<0.001
Pneumonia	68 (54.84)	80 (57.14)	64 (45.71)	0.131
COPD	5 (4.03)	7 (5.00)	4 (2.86)	0.655
Renal replacement therapy	4 (3.23)	14 (10.00)	26 (18.57)	<0.001
Laboratory parameters
Bicarbonate, mmol/L	24.60 ± 4.20	25.65 ± 4.77	24.19 ± 4.90	0.027
Creatinine, mEq/L	1.35 ± 1.28	1.50 ± 1.38	2.10 ± 1.76	<0.001
Glucose, mg/dl	194.54 ± 117.55	183.37 ± 87.12	184.79 ± 95.91	0.623
WBC, 10^9/L	14.83 ± 6.26	15.94 ± 8.65	19.39 ± 45.41	0.365
Hematocrit, %	38.02 ± 5.36	35.73 ± 5.68	32.14 ± 5.52	<0.001
Hemoglobin, g/dl	12.92 ± 1.88	11.94 ± 1.92	10.60 ± 1.88	<0.001
Platelet, 10^9/L	261.56 ± 99.36	291.76 ± 145.93	227.00 ± 155.77	<0.001
Sodium, mmol/L	140.27 ± 5.46	140.91 ± 4.97	140.16 ± 5.59	0.444
Chloride, mmol/L	107.09 ± 7.06	107.36 ± 6.65	106.07 ± 6.90	0.256
Potassium, mmol/L	4.69 ± 1.54	4.65 ± 0.85	4.68 ± 0.91	0.953
BUN, mg/dl	24.93 ± 17.93	31.09 ± 21.45	42.66 ± 29.72	<0.001
Aniongap, mmol/L	16.53 ± 4.36	16.09 ± 3.55	17.76 ± 5.37	0.006
PT, second	15.28 ± 5.81	15.61 ± 3.82	18.66 ± 7.87	<0.001
APTT, second	43.74 ± 32.96	45.18 ± 32.21	47.46 ± 29.95	0.654
INR	1.64 ± 2.33	1.58 ± 0.82	1.98 ± 1.27	0.093
Scoring systems
SOFA	4.85 ± 3.26	5.04 ± 3.12	6.34 ± 4.05	<0.001
SAPSII	37.27 ± 13.85	40.16 ± 14.21	43.56 ± 15.69	0.002
30-day mortality, n (%)	21 (16.94)	34 (24.29)	42 (30.00)	0.046
90-day mortality, n (%)	27 (21.77)	43 (30.71)	58 (41.43)	0.003

ICU: intensive care unit; SBP: systolic blood pressure; DBP: diastolic blood pressure; MBP: mean blood pressure; SPO2: blood oxygen saturation; AKI: acute kidney injury; COPD: chronic obstructive pulmonary disease; WBC: white blood cell; BUN: blood urea nitrogen; PT: prothrombin time; APTT: activated partial thromboplastin time; INR: international normalized ratio; SOFA: sequential organ failure assessment; SAPSII: simplified acute physiology score II.