Research Article
Role of MMP-2(-1306 C/T) and TIMP-2(-418G/C) Polymorphism in Chinese Han Patients with Acne Vulgaris
Table 3
Genotype frequencies of MMP-2 (-1306C/T) and TIMP-2 (-418G/C) polymorphism in acne patients and controls.
| Genes | Controls | Patients | OR (95%CI) | P | n=121 (%) | n=251 (%) |
| MMP-2 (-1306) C>T | | | | | CC | 107 (84.4) | 170 (67.7) | Reference | | CT | 14 (11.6) | 78 (31.1) | 0.285 (0.154-0.529) | <0.001 | TT | 0 (0) | 3 (1.2) | 0.614 (0.559-0.674) | 0.171 | CT+TT | 14 (11.6) | 81 (32.3) | 0.275 (0.148-0.509) | <0.001 | Allele | | | | | C | 228 (94.2) | 418 (83.2) | Reference | | T | 14 (5.8) | 84 (16.7) | 0.306 (0.170-0.550) | <0.001 | TIMP-2 (-418) G>C | | | | | GG | 89 (73.6) | 171 (68.1) | Reference | | GC | 29 (23.9) | 68 (27.1) | 1.220 (0.737-2.021) | 0.439 | CC | 3 (2.5) | 12 (4.8) | 2.082 (0.573-7.569) | 0.256 | GC+CC | 32 (26.4) | 80 (31.9) | 1.301 (0.802-2.110) | 0.285 | Allele | | | | | G | 207 (85.5) | 410 (81.7) | Reference | | C | 35 (14.5) | 92 (18.3) | 1.327 (0.869-2.027) | 0.189 |
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OR: odds ratio adjusted by acne patients and controls; CI: confidence interval.
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