Role of MMP-2(-1306 C/T) and TIMP-2(-418G/C) Polymorphism in Chinese Han Patients with Acne Vulgaris

Table 3

Genotype frequencies of MMP-2 (-1306C/T) and TIMP-2 (-418G/C) polymorphism in acne patients and controls.

Genes	Controls	Patients	OR (95%CI)	P
	n=121 (%)	n=251 (%)
MMP-2 (-1306) C>T
CC	107 (84.4)	170 (67.7)	Reference
CT	14 (11.6)	78 (31.1)	0.285 (0.154-0.529)	<0.001
TT	0 (0)	3 (1.2)	0.614 (0.559-0.674)	0.171
CT+TT	14 (11.6)	81 (32.3)	0.275 (0.148-0.509)	<0.001
Allele
C	228 (94.2)	418 (83.2)	Reference
T	14 (5.8)	84 (16.7)	0.306 (0.170-0.550)	<0.001
TIMP-2 (-418) G>C
GG	89 (73.6)	171 (68.1)	Reference
GC	29 (23.9)	68 (27.1)	1.220 (0.737-2.021)	0.439
CC	3 (2.5)	12 (4.8)	2.082 (0.573-7.569)	0.256
GC+CC	32 (26.4)	80 (31.9)	1.301 (0.802-2.110)	0.285
Allele
G	207 (85.5)	410 (81.7)	Reference
C	35 (14.5)	92 (18.3)	1.327 (0.869-2.027)	0.189

OR: odds ratio adjusted by acne patients and controls; CI: confidence interval.