Combination of Sodium Selenite and Doxorubicin Prodrug Ac-Phe-Lys-PABC-ADM Affects Gastric Cancer Cell Apoptosis in Xenografted Mice

Figure 4

Western blot of proteins associated with cell cycle and apoptosis. (a, b) Western blot and quantification of cell cycle-associated proteins (cyclin D1, cyclin E, Ki67, and CDK4). (c–e) Western blot and quantification of apoptosis-related proteins (cleaved caspase-3, cleaved caspase-9, Bax, Bcl-2, and P53) and mitochondrial apoptosis-related proteins (Smac and APAF1). All data are presented as the mean ± SD, n = 3. P < 0.05, P < 0.01, P < 0.001 vs. control; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. SS+PADM.

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