Glypican-3 Enhances Reprogramming of Glucose Metabolism in Liver Cancer Cells

Figure 2

GPC3 enhanced the Warburg effect through upregulation of glycolytic enzymes. (a and b) qRT-PCR and western blot analyses for expression levels of glycolytic enzymes of Glut1, HK2, and LDH-A in HLE and HLF cells with treatment as indicated. (c) Representative immunohistochemical (IHC) staining images of GPC3, Glut1, HK2, and LDH-A in tumor tissues from 50 LC patients. (d) Spearman correlation analysis between expression levels of GPC3 and Glut1, HK2, and LDH-A in LC tissues. Data shown are the mean ± SEM from three independent experiments. ; .

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