Glypican-3 Enhances Reprogramming of Glucose Metabolism in Liver Cancer Cells

<div>GPC3 suppressed mitochondrial OXPHOS through downregulation of PGC-1<i>α</i>. (a and b) qRT-PCR and western blot analyses for PGC-1<i>α</i> expression level in HLE and HLF cells with treatment as indicated. (c) Representative immunohistochemical (IHC) staining images of GPC3 and PGC-1<i>α</i> in tumor tissues from 50 LC patients. (d) Spearman correlation analysis between the expression levels of GPC3 and PGC-1<i>α</i> in 50 LC tissues based on the IHC staining results. 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BioMed Research International

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Figure 3

Figure 3: Glypican-3 Enhances Reprogramming of Glucose Metabolism in Liver Cancer Cells 