BioMed Research International

Research Article

Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer

Table 1

The transcription levels of MT family isoforms between different types of GC and normal tissues (ONCOMINE).


MT family members	Types of GC vs. normal	Fold change	t-Test	P value	Reporter

MT1A	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.939	-5.52	1.48E-06	ILMN-1691156
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.151	-6.36	1.04E-07	ILMN-1691156
	Gastric Mixed Adenocarcinoma vs. Normal	-3.053	-3.47	2.00E-03	ILMN-1691156
	Gastric Adenocarcinoma vs. Normal	-2.255	-0.99	0.196	ILMN-1691156

MT1B	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.496	-7.43	3.42E-09	IMAGE:232772
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.037	-4.43	5.52E-05	IMAGE:232772
	Gastric Mixed Adenocarcinoma vs. Normal	-2.321	-4.43	2.26E-04	IMAGE:232772
	Gastric Cancer vs. Normal	-1.327^▲	-1.65	0.051	3662190
	Gastric Mixed Adenocarcinoma vs. Normal	-1.111^▲	-1.31	0.102	ILMN-1733758
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.065^▲	-0.73	0.236	ILMN-1733758
	Diffuse Gastric Adenocarcinoma vs. Normal	1.025	0.223	0.588	ILMN-1733758
	Gastric Adenocarcinoma vs. Normal	1.326	0.793	0.76	ILMN-1733758

MT1E	Gastric Mixed Adenocarcinoma vs. Normal	-3.006	-7.8	1.16E-08	ILMN-1718968
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-3.014	-7.81	1.99E-09	ILMN-1718968
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.042	-8.23	6.09E-10	ILMN-1718968
	Gastric Adenocarcinoma vs. Normal	-2.524	-4.05	0.005	ILMN-1718968
	Gastric Cancer vs. Normal	-3.942	-3.17	9.14E-04	3662139
	Gastric Mixed Adenocarcinoma vs. Normal	-5.468	-5.12	0.005	212859-x-at
	Gastric Cancer vs. Normal	-2.435	-2.79	0.006	212859-x-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-1.97^▲	-2.66	0.018	212859-x-at
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.74^▲	-3.17	0.001	212859-x-at

MT1F	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.011	-10.9	7.66E-14	IMAGE:78353
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.821	-6.8	6.50E-08	IMAGE:78353
	Gastric Mixed Adenocarcinoma vs. Normal	-4.273	-4.69	3.35E-04	IMAGE:245990
	Diffuse Gastric Adenocarcinoma vs. Normal	-4.486	-8.37	2.13E-10	ILMN-1718766
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-3.911	-6.22	1.69E-07	ILMN-1718766
	Gastric Mixed Adenocarcinoma vs. Normal	-4.355	-3.73	0.001	ILMN-1718766
	Gastric Mixed Adenocarcinoma vs. Normal	-4.283	-10.5	4.58E-06	213629-x-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.712	-4.1	0.003	213629-x-at
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.095	-4.22	5.69E-05	217165-x-at
	Gastric Cancer vs. Normal	-3.148	-3.12	0.003	213629-x-at
	Gastric Adenocarcinoma vs. Normal	-2.514	-0.81	0.237	ILMN-1718766

MT1G	Gastric Cancer vs. Normal	-3.231	-6.53	4.28E-10	3692999
	Diffuse Gastric Adenocarcinoma vs. Normal	-4.274	-6.82	4.25E-08	IMAGE:202535
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.68	-10	1.04E-12	IMAGE:202535
	Gastric Mixed Adenocarcinoma vs. Normal	-5.508	-5.68	7.17E-05	IMAGE:202535
	Diffuse Gastric Adenocarcinoma vs. Normal	-4.092	-6.15	1.43E-04	204745-x-at
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.636	-5.41	1.02E-06	204745-x-at
	Gastric Mixed Adenocarcinoma vs. Normal	-6.734	-8.01	3.57E-04	204745-x-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-8.187	-8.02	1.19E-10	ILMN-1715401
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-6.637	-6.24	2.22E-07	ILMN-1715401
	Gastric Mixed Adenocarcinoma vs. Normal	-4.742	-3.31	0.003	ILMN-1715401
	Gastric Cancer vs. Normal	-4.655	-3.41	0.001	210472-at
	Gastric Adenocarcinoma vs. Normal	-3.824	-1.15	0.165	ILMN-1715401

MT1H	Gastric Intestinal Type Adenocarcinoma vs. Normal	-4.137	-9.59	1.06E-12	IMAGE:214162
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.314	-5.99	1.13E-06	IMAGE:214162
	Gastric Mixed Adenocarcinoma vs. Normal	-4.151	-4.5	8.45E-04	IMAGE:214162
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.076	-5.1	4.59E-04	206461-x-at
	Gastric Mixed Adenocarcinoma vs. Normal	-4.261	-7.53	1.72E-04	206461-x-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-6.768	-6.77	5.16E-08	ILMN-2124802
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.882	-5.4	2.04E-06	ILMN-2124802
	Gastric Mixed Adenocarcinoma vs. Normal	-4.122	-2.75	0.008	ILMN-2124802
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.84^▲	-3.76	2.21E-04	206461-x-at
	Gastric Adenocarcinoma vs. Normal	-2.701	-0.85	0.228	ILMN-2124802
	Gastric Cancer vs. Normal	-1.32^▲	-2.25	0.013	2462589

MT1M	Gastric Cancer vs. Normal	-4.451	-7.56	1.68E-12	3662150
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.442	-11.2	8.37E-17	IMAGE:126458
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.75	-6.3	9.03E-07	IMAGE:126458
	Gastric Mixed Adenocarcinoma vs. Normal	-6.244	-6.14	1.15E-04	IMAGE:126458
	Diffuse Gastric Adenocarcinoma vs. Normal	-8.169	-9	7.18E-10	ILMN-1657435
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.42	-6.12	2.48E-07	ILMN-1657435
	Gastric Mixed Adenocarcinoma vs. Normal	-3.749	-3.03	0.004	ILMN-1657435
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-5.088	-6.1	2.23E-07	217546-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-4.402	-3.57	0.006	217546-at
	Gastric Cancer vs. Normal	-10.35	-3.32	0.003	217546-at
	Gastric Adenocarcinoma vs. Normal	-1.999^▲	-0.87	0.221	ILMN-1657435

MT1X	Gastric Intestinal Type Adenocarcinoma vs. Normal	-3.75	-9.04	8.45E-12	IMAGE:297392
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.85	-5.07	1.17E-05	IMAGE:297392
	Gastric Mixed Adenocarcinoma vs. Normal	-3.223	-4.26	6.15E-04	IMAGE:297392
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-4.098	-6.29	1.63E-07	ILMN-1775170
	Diffuse Gastric Adenocarcinoma vs. Normal	-3.782	-6.42	1.60E-07	ILMN-1775170
	Gastric Mixed Adenocarcinoma vs. Normal	-3.21	-3.71	8.60E-04	ILMN-1775170
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.371	-4.44	0.001	208581-x-at
	Gastric Mixed Adenocarcinoma vs. Normal	-3.11	-4.86	0.004	208581-x-at
	Gastric Cancer vs. Normal	-3.261	-4.92	1.09E-06	3662247
	Gastric Adenocarcinoma vs. Normal	-2.329	-1.1	0.172	ILMN-1775170
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.55^▲	-2.95	0.002	208581-x-at
	Gastric Cancer vs. Normal	-1.99^▲	-2.18	0.021	208581-x-at

MT2A	Diffuse Gastric Adenocarcinoma vs. Normal	-2.117	-4.32	0.001	212185-x-at
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.308	-4.56	2.50E-05	ILMN-1686664
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.153	-3.85	2.25E-04	ILMN-1686664
	Gastric Mixed Adenocarcinoma vs. Normal	-2.68	-3.67	9.96E-04	ILMN-1686664
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.42^▲	-2.7	0.005	208581-x-at
	Gastric Adenocarcinoma vs. Normal	-1.89^▲	-0.86	0.224	ILMN-1686664
	Gastric Cancer vs. Normal	-1.87^▲	-2.33	0.015	212185-x-at

MT3	Gastric Intestinal Type Adenocarcinoma vs. Normal	-2.85	-8.47	1.47E-10	IMAGE:2019011
	Diffuse Gastric Adenocarcinoma vs. Normal	-2.312	-5.22	5.48E-06	IMAGE:2019011
	Gastric Mixed Adenocarcinoma vs. Normal	-2.688	-4.68	2.23E-04	IMAGE:2019011
	Diffuse Gastric Adenocarcinoma vs. Normal	-1.21^▲	-3.71	3.47E-04	ILMN-1675947
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.14^▲	-1.89	0.034	ILMN-1675947
	Gastric Mixed Adenocarcinoma vs. Normal	-1.11^▲	-0.77	0.229	ILMN-1675947
	Gastric Adenocarcinoma vs. Normal	1.107	0.315	0.614	ILMN-1675947
	Gastric Cancer vs. Normal	-1.24^▲	-2.81	0.003	3662093
	Diffuse Gastric Adenocarcinoma vs. Normal	-1.79^▲	-1.63	0.079	205970-at
	Gastric Mixed Adenocarcinoma vs. Normal	-1.97^▲	-2.04	0.061	205970-at
	Gastric Intestinal Type Adenocarcinoma vs. Normal	-1.21^▲	-1.33	0.096	205970-at
	Gastric Cancer vs. Normal	-1.19^▲	-0.57	0.288	205970-at

MT4	Gastric Cancer vs. Normal	-2.723	-5.62	5.26E-08	3662086
	Gastric Mixed Adenocarcinoma vs. Normal	1.02	0.673	0.744	ILMN-1745345
	Diffuse Gastric Adenocarcinoma vs. Normal	1.018	1.026	0.844	ILMN-1745345
	Gastric Intestinal Type Adenocarcinoma vs. Normal	1.032	1.191	0.879	ILMN-1745345
	Gastric Adenocarcinoma vs. Normal	1.461	1.104	0.825	ILMN-1745345

Notes: P value was analyzed using the t-test. The bold font indicates that the difference was not statistically significant between the GC and normal tissue group. The bold font with symbol “^▲” indicates the fold change was no more than 2 folds. The bold font with symbol “” indicates the transcription level of MTs in gastric cancer was slightly higher than normal tissue.