Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer
Table 2
The prognostic values of MT isoforms in different pathological subtypes of GC patients (Kaplan-Meier plotter).
MT family
Lauren classification
OS
PPS
cases
HR
95%CI
P value
cases
HR
95%CI
P value
MT1E
intestinal
320
0.67
0.49-0.92
0.013
192
1.39
0.92-2.1
0.12
diffuse
241
0.55
0.38-0.79
0.0011
176
0.53
0.34-0.83
0.0045
mixed
32
5.92
0.77-45.35
0.053
16
–
–
–
MT1F
intestinal
320
0.63
0.46-0.88
0.0056
192
0.7
0.45-1.09
0.11
diffuse
241
0.62
0.44-0.88
0.0063
176
0.48
0.3-0.77
0.0019
mixed
32
2.02
0.68-5.99
0.2
16
–
–
–
MT1G
intestinal
320
1.99
1.42-2.8
0.00005
192
2.6
1.7-3.97
4.3E-05
diffuse
241
1.83
1.18-2.82
0.006
176
1.53
1.03-2.28
0.034
mixed
32
3.32
1.3-9.82
0.021
16
–
–
–
MT1H
intestinal
320
0.7
0.5-1
0.046
192
0.63
0.4-1.0
0.047
diffuse
241
0.55
0.39-0.77
0.00053
176
0.54
0.36-0.79
0.0015
mixed
32
0.33
0.07-1.47
0.13
16
–
–
–
MT1M
intestinal
320
0.59
0.42-0.84
0.0027
192
1.48
0.98-2.25
0.061
diffuse
241
0.59
0.39-0.89
0.011
176
0.54
0.34-0.84
0.0051
mixed
32
1.57
0.57-4.36
0.38
16
–
–
–
MT1X
intestinal
320
0.58
0.42-0.82
0.0015
192
0.65
0.42-0.99
0.041
diffuse
241
0.57
0.4-0.79
0.00087
176
0.56
0.38-0.83
0.0029
mixed
32
0.49
0.14-1.75
0.26
16
–
–
–
MT2A
intestinal
320
1.27
0.93-1.75
0.13
192
1.49
0.99-2.25
0.055
diffuse
241
0.59
0.41-0.86
0.0047
176
0.65
0.44-0.97
0.035
mixed
32
0.52
0.18-1.51
0.22
16
–
–
–
MT3
intestinal
320
2.34
1.69-3.26
1.8E-06
192
1.79
1.18-2.7
0.0051
diffuse
241
1.24
0.83-1.86
0.29
176
1.23
0.78-1.94
0.37
mixed
32
1.43
0.49-4.2
0.51
16
–
–
–
MT4
intestinal
320
2.58
1.87-3.56
1.8E-08
192
2.48
1.4-4.4
0.0013
diffuse
241
0.72
0.52-1.02
0.06
176
1.5
0.96-2.33
0.07
mixed
32
2.8
1.01-7.77
0.038
16
–
–
–
Notes: P value was analyzed using the survival analysis test. The fold indicates that the difference was statically significant. The P value was set up at 0.05. Abbreviations: GC: gastric cancer; OS: overall survival; PPS: postprogression survival; HR: hazard ratio.
