Research Article
Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MS/MS
Table 2
Main pharmacokinetic parameters of delavinone in mice.
| Parameters | Unit | iv (1.0 mg/kg) | ig (2.5 mg/kg) | ig (10 mg/kg) |
| | ng/mLh | 169.8±44.2 | 48.0 ±7.0 | 229.7 ±49.6 | | ng/mL h | 245.2 ±106.1 | 60.8 ±12.4 | 241.4 ±52.5 | | h | 1.4 ±0.1 | 2.5 ±0.2 | 1.4 ±0.2 | | h | 9.2 ±6.3 | 4.8 ±1.0 | 1.9 ±0.4 | | h | 9.5 ±5.2 | 4.1 ±0.9 | 2.7±0.8 | | L/h/kg | 4.7 ±1.8 | 42.6 ±8.8 | 43.0±8.6 | | L/kg | 46.4 ±31.9 | 242.2 ±36.0 | 162.3±51.3 | | ng/mL | 183.7 ±33.5 | 21.3 ±6.5 | 196.9±83.3 | Bioavailability | | 11.3% | 13.5% |
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