Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MS/MS

Table 2

Main pharmacokinetic parameters of delavinone in mice.

Parameters	Unit	iv (1.0 mg/kg)	ig (2.5 mg/kg)	ig (10 mg/kg)
	ng/mLh	169.8±44.2	48.0 ±7.0	229.7 ±49.6
	ng/mL h	245.2 ±106.1	60.8 ±12.4	241.4 ±52.5
	h	1.4 ±0.1	2.5 ±0.2	1.4 ±0.2
	h	9.2 ±6.3	4.8 ±1.0	1.9 ±0.4
	h	9.5 ±5.2	4.1 ±0.9	2.7±0.8
	L/h/kg	4.7 ±1.8	42.6 ±8.8	43.0±8.6
	L/kg	46.4 ±31.9	242.2 ±36.0	162.3±51.3
	ng/mL	183.7 ±33.5	21.3 ±6.5	196.9±83.3
Bioavailability			11.3%	13.5%