|
| Treatment | Experimental model | Effects | Ref. |
|
| Quercetin | Rats treated with 50% ethanol for 10 days | Prevents ethanol-induced liver injury by enhancing antioxidative activity and suppressing the induction of cytokines, chemokines | Chen et al. [18] |
| Quercetin | Rats administrated with alcohol (4.0 g/kg) for 90 days | Protects against chronic ethanol toxicity through its hypolipidemic effect and antioxidative role | Tang et al. [19] |
| Quercetin | Rats administrated with alcohol (4.0 g/kg) for 90 days | Attenuates ethanol-derived microsomal oxidative stress by suppressing the downregulation of HO-1 and the induction of CYP2E1 | Tang et al. [20] |
| Quercetin | Rats treated with ethanol (2.0 g/kg) for 30 days | Prevents long-term alcohol consumption-induced oxidative stress and cytokines | Kahraman et al. [21] |
| Quercetin | Mice fed with Lieber-deCarli alcohol-liquid diets for 15 weeks | Alleviates ethanol-elicited mitochondrial damage through enhancing AMPK- and ERK2-mediated mitophagy | Yu et al. [22] |
| Luteolin | Mice exposed to alcohol (1%, 2%, and 4% for 3 d, and 5% for 9 d) and a binge (30% ethanol) on the last day | Ameliorates ethanol-induced hepatic steatosis and injury by activating AMPK and suppressing SREBP-1c/FAS pathway | Liu et al. [23] |
| Apigenin | Mice given 56% erguotou wine by gavage for 30 days | Exerts a protective effect on alcohol-induced liver injury by regulating hepatic CYP2E1-mediated oxidative stress and PPARα, SREBP-1c and FAS gene expression | Wang et al. [24] |
| Fisetin | Mice given 50% ethanol p.o. (10 ml/kg body weight) every 12 hours for a total of 5 doses | Ameliorate alcohol-induced hepatic damage by restoring the antioxidant and MMP/TIMP balance | Koneru et al. [25] |
| Fisetin | Mice fed with Lieber-deCarli alcohol-liquid diets for 4 weeks | Attenuates alcohol-induced hepatic steatosis by increasing hepatic protein levels of p-AMPK, ACOX1, CYP4A, and MTTP | Sun et al. [26] |
| Baicalin | Rats intragastrically administrated with alcohol continuously for 4 or 8 weeks | Exerts beneficial effects on alcohol-induced liver injury through inhibiting oxidative stress, proinflammatory cytokines expression, and the regulation of the sonic hedgehog pathway | Wang et al. [27] |
| Baicalin | Mice treated by chronic plus binge ethanol feeding | Ameliorates ethanol-induced liver injury by modulating oxidative stress and inflammation via CYP2E1 and NRF2 | He et al. [28] |
| Puerarin | Rats treated with 40% ethanol (8 g/kg/d) for 5 days | Prevents acute ALD by enhancing antioxidative capacity | Zhao et al. [29] |
| Puerarin | Rats provided with the Liber-deCarli liquid diet for 8 weeks | Alleviates chronic alcoholic liver injury by inhibiting endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression | Peng et al. [30] |
| Puerarin | Rats treated with 6 g/kg/d, 7 g/kg/d, 8 g/kg/d (for a period of 1 week respectively), and 9 g/kg/d (for a period of 21 weeks) of 56% alcohol | Protects against alcohol-induced liver lesions through improving metabolic function | Chen et al. [31] |
| Puerarin/ Genistein | Mice gastrically infused with 50% alcohol once per day for 5 weeks | Alleviates hepatic damage induced by chronic alcohol administration through potential antioxidant, anti-inflammatory, or anti-apoptotic mechanisms | Zhao et al. [32] |
| Genistein | Rats underwent intragastric administration of alcohol (5.0–9.5 g/kg) once a day for 24 weeks | Ameliorates ethanol-induced liver injury and even liver fibrosis by decreasing oxidative stress and production of inflammatory and by inhibiting fibrogenic mediators | Huang et al. [33] |
| Curcumin | Rats treated with ethanol (starting dose was 8 g/kg/d and final dose was 16 g/kg/d) plus fish oil for 4 weeks | Prevents experimental ALD by suppressing the activation of NF-κB and the induction of cytokines, chemokines | Nanji et al. [34] |
| Curcumin | Mice treated with ethanol (2.4 g/kg/day ethanol for the initial 4 weeks and 4 g/kg/day for another 2 weeks) | Prevents chronic ALD by decreasing ROS generation and enhancing antioxidative capacity | Rong et al. [35] |
| Curcumin | Mice administered orally with alcohol (5 g/kg body weight) once a day for 6 weeks and fed a high-fat diet | Protects alcohol-induced liver damage by modulating alcohol metabolic pathway, enhancing antioxidant activity and activating AMPK | Lee et al. [36] |
| Curcumin | Rats given ethanol (56% v/v, 10 mL/kg) orally once every day for 9 weeks | Attenuates ALD by modulating lipid deposition in hepatocytes via a Nrf2/FXR activation and modulating the expression of SREBP-1c, fatty acid synthase, and PPAR-α | Lu et al. [37] |
| Curcumin | Mice given 2.4 g/kg/day ethanol plus olive oil once a day for 6 weeks | Protects the liver from chronic-ethanol induced injury through attenuating oxidative stress, at least partially, through ERK/p38/Nrf2-mediated anti-oxidant signaling pathways | Xiong et al. [38] |
| Curcumin | Rats fed with Lieber-deCarli low menhaden and high menhaden alcohol-liquid diets for 8 weeks | Protects against chronic alcohol-induced liver injury by enhancing antioxidative capacity | Varatharajalu et al. [39] |
| Curcumin | Mice fed with Lieber-deCarli alcohol-liquid diets for 4 weeks | Improves alcoholic fatty liver by inhibiting biosynthesis of unsaturated fatty acids, fatty acid biosynthesis and pentose and glucuronate interconversions | Guo et al. [40] |
| Curcumin | Rats fed 50% ethanol (7.5 g/kg body weight/day) orally twice a day for 4 weeks | Improves ethanol-induced liver injury by reducing oxidative stress and inhibiting NF-κB activation | Samuhasaneeto et al. [41] |
| Ellagic acid | Rats fed 20% alcohol orally (7.9 g/kg body weight) for 45 days | Exerts beneficial effects against alcohol-induced damage | Devipriya et al. [42] |
| Ellagic acid | Rats fed 20% alcohol orally (7.9 g/kg body weight) for 45 days | Decreases the expression pattern of fibrotic markers during alcohol-induced toxicity | Devipriya et al. [43] |
| Ellagic acid | Mice fed with Lieber-deCarli alcohol-liquid diets for 5 weeks | Improves alcoholic fatty liver by suppressing the expression of the genes related to cell stress and up-regulating the genes involved in bile acid synthesis, unsaturated fatty acid elongation, and tetrahydrofolate synthesis | Yao et al. [44] |
| Silymarin /Silybin | Mice received ethanol (5 g/kg body weight) by gavage every 12 hours for a total of 3 doses | Protects against the acute alcoholic liver injury by decreasing oxidative stress and production of inflammatory cytokines | Song et al. [45] |
| Silymarin /Silybin | Mice fed ethanol (1.6 g/kg body weight) for 12 weeks | Prevents long-term alcohol consumption-induced liver injury by enhancing antioxidant activity and suppressing the induction of cytokines | Das et al. [46] |
| Chlorogenic acid | Mice fed ethanol (3 g/kg body weight) for 7 consecutive days | Prevents ethanol-induced acute liver injury by reducing oxidative stress, steatosis, apoptotic cell death, and fibrosis | Kim et al. [47] |
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