Research Article
Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives
Table 2
MFC values (μmol/mL) and MFC/MIC ratio for compounds 1-12.
| Compounds | Candida albicans | Candida glabrata | Candida krusei | Candida guilliermondi | (ATCC 90028) | (ATCC 90030) | (ATCC 34135) | (ATCC 22017) | MFC | MFC/MIC | MFC | MFC/MIC | MFC | MFC/MIC | MFC | MFC/MIC |
| 1 | 10.18 | 2 | 5.09 | 1 | + | 1.27 | 1 |
| 2 | 4.75 | 1 | 4.75 | 1 | 4.75 | 1 | 1.19 | 1 |
| 3 | + | + | + | 2.22 | 1 |
| 4 | + | + | + | 2.22 | 1 |
| 5 | + | 4.19 | 1 | + | 2.09 | 1 |
| 6 | 2.08 | 1 | 2.08 | 1 | 4.16 | 1 | 0.13 | 1 |
| 7 | + | 3.96 | 1 | + | + |
| 8 | 3.10 | 1 | 3.10 | 1 | 3.10 | 1 | 1.55 | 2 |
| 9 | + | + | + | 0.40 | 1 |
| 10 | + | + | + | 0.41 | 1 |
| 11 | 1.58 | 1 | 1.58 | 1 | 0.78 | 1 | 0.024 | 1 |
| 12 | 2.85 | 1 | 2.85 | 1 | 2.85 | 1 | + |
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(+) The compounds present no MFC. MFC/MIC relation ≥ 4: fungistatic activity. MFC/MIC < 4: fungicidal activity [ 14]. MFC: minimal fungicidal concentration; MIC: minimum inhibitory concentration. |