Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

Table 2

Effect of crude extract of C. aurantium on urine output in rats treated with cisplatin.

Days of observation
Groups	0^th day	7^thday	14^thday	21^stday
Control	7.2 ± 1.8	7.0 ± 1.8	7.5 ± 1.7	6.3 ± 1.1
Cisplatin	7.0 ± 1.8	31 ± 2.2	31 ± 3.0	33 ± 1.5
Cisplatin + C. aurantium (200 mg/kg)	8.0 ± 1.7	23 ± 1.8	24 ± 8.3	22 ± 1.2
Cisplatin + C. aurantium (400 mg/kg)	7.2 ± 1.6	15 ± 1.4	16 ± 1.6	17 ± 0.88

Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . , . Results were compared in a column with the respective control values.