Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

Table 6

Effect of crude extract of C. aurantium on absolute creatinine clearance in rats treated with cisplatin.

		Days of observation
Parameter	Groups	0^th day	7^th day	14^th day	21^st day
Absolute creatinine clearance	Control	0.27 ± 0.024	0.42 ± 0.016	0.40 ± 0.011	0.86 ± 0.024
	Cisplatin	0.26 ± 0.036	0.33 ± 0.019	0.31 ± 0.014	0.40 ± 0.028
	Cisplatin + C. aurantium (200 mg/kg)	0.26 ± 0.028	0.49 ± 0.015	0.53 ± 0.037	0.66 ± 0.054
	Cisplatin + C. aurantium (400 mg/kg)	0.29 ± 0.037	0.61 ± 0.030	0.73 ± 0.031	1.2 ± 0.096

Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . , , indicates . Results were compared in a column with the respective control values.