Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

Table 9

Effect of crude extract of C. aurantium on fractional excretion of potassium and sodium in rats treated with cisplatin.

		Days of observation
Parameter	Groups	0^th day	7^th day	14^th day	21^st day
Fractional excretion of potassium	Control	3.8 ± 0.48	5.6 ± 1.4	10 ± 2.3	9.2 ± 1.6
	Cisplatin	3.8 ± 0.29	17 ± 3.2	24 ± 3.5	26 ± 2.8
	Cisplatin + C. aurantium (200 mg/kg)	3.6 ± 0.23	12 ± 2.0	19 ± 2.6	19 ± 2.1
	Cisplatin + C. aurantium (400 mg/kg)	3.7 ± 0.48	8.3 ± 1.8	14 ± 2.3	13 ± 1.6
Fractional excretion of sodium	Control	0.28 ± 0.036	0.30 ± 0.06	0.33 ± 0.09	0.30 ± 0.05
	Cisplatin	0.26 ± 0.044	0.77 ± 0.25	0.61 ± 00.16	0.69 ± 0.09
	Cisplatin + C. aurantium (200 mg/kg)	0.27 ± 0.07	0.62 ± 0.22	0.49 ± 0.11	0.53 ± 0.06
	Cisplatin C. aurantium (400 mg/kg)	0.32 ± 0.14	0.43 ± 0.12	0.03 ± 0.009	0.35 ± 0.05

Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . , . Results were compared in a column with the respective control values.