Reversing Effect of Insulin on Local Anesthetics-Induced Sciatic Nerve Block in Rats

Table 1

Short-acting insulin can reverse lidocaine- or bupivacaine-induced sciatic nerves local anesthesia.

	Sciatic nerve recovery (min)
	start	complete
Lidocaine + normal saline	48 ± 6	58 ± 16
Lidocaine + insulin	16 ± 2^#	17 ± 3^#
Bupivacaine + normal saline	108 ± 19	116 ± 16
Bupivacaine + insulin	30 ± 5	36 ± 4

Results are presented as mean ± SD (n = 8).
“Start” means that small amplitude of the action potential appears as recovery from local anesthesia. “Complete” means that when the action potential amplitude is recovered as much as preanesthetics level.
Insulin is a short-acting insulin, Humulin R®.
^#Significant difference from lidocaine + normal saline group at p < 0.01.
Significant difference from bupivacaine + normal saline group at p < 0.01.