Research Article
Rs4846049 Polymorphism at the 3′-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia
Table 1
Association of rs4846049 polymorphism and the risk of ALL.
| | | | ALL (n = 110) | Control (n = 105) | value | OR (95% CI) |
| | Overall | Allele | | | | | | G | 182 (82.7) | 165 (78.6) | — | 1.000 | | T | 38 (17.3) | 45 (21.4) | 0.328 | 0.766 (0.474–1.238) | | Codominant | | | | | | GG | 75 (68.2) | 67 (63.8) | — | 1.000 | | GT | 32 (29.1) | 31 (29.5) | 0.880 | 0.922 (0.509–1.670) | | TT | 3 (2.7) | 7 (6.7) | 0.201 | 0.383 (0.095–1.540) | | Dominant | | | | | | GG | 75 (68.2) | 67 (63.8) | — | 1.000 | | GT + TT | 35 (31.8) | 38 (36.2) | 0.565 | 0.823 (0.468–1.448) | | Recessive | | | | | | GG + GT | 107 (97.3) | 98 (93.3) | — | 1.000 | | TT | 3 (2.7) | 7 (6.7) | 0.207 | 0.393 (0.099–1.560) | | Overdominant | | | | | | GG + TT | 78 (70.9) | 74 (70.5) | — | 1.000 | | GT | 32 (29.1) | 31 (29.5) | 1.000 | 0.979 (0.544–1.762) |
| | Age ≤8 years | Allele | | | | | | G | 150 (80.6) | 135 (81.3) | — | 1.000 | | T | 36 (19.4) | 31 (18.7) | 0.893 | 1.045 (0.613–1.782) | | Codominant | | | | | | GG | 60 (64.5) | 56 (67.5) | — | 1 | | GT | 30 (32.3) | 23 (27.7) | 0.619 | 1.217 (0.633–2.341) | | TT | 3 (3.2) | 4 (4.8) | 0.713 | 0.700 (0.150–3.267) | | Dominant | | | | | | GG | 60 (64.5) | 56 (67.5) | — | 1 | | GT + TT | 33 (35.5) | 27 (32.5) | 0.751 | 1.141 (0.610–2.132) | | Recessive | | | | | | GG + GT | 90 (96.8) | 79 (95.2) | — | 1 | | TT | 3 (3.2) | 4 (4.8) | 0.708 | 0.658 (0.143–3.032) | | Overdominant | | | | | | GG + TT | 63 (67.7) | 60 (72.3) | — | 1 | | GT | 30 (32.3) | 23 (27.7) | 0.622 | 1.242 (0.650–2.375) |
| | Age >8 years | Allele | | | | | | G | 32 (94.1) | 30 (68.2) | — | 1.000 | | T | 2 (5.9) | 14 (31.8) | 0.005 | 0.134 (0.028–0.639) | | Codominant | | | | | | GG | 15 (88.2) | 11 (50.0) | — | 1.000 | | GT | 2 (11.8) | 8 (36.4) | 0.065 | 0.183 (0.032–1.038) | | TT | 0 (0.0) | 3 (13.6) | 0.100 | 1.273 (0.968–1.673) | | Dominant | | | | | | GG | 15 (88.2) | 11 (50) | — | 1.000 | | GT + TT | 2 (11.8) | 11 (50) | 0.017 | 0.133 (0.024–0.727) | | Recessive | | | | | | GG + GT | 17 (100.0) | 19 (86.4) | — | 1.000 | | TT | 0 (0.0) | 3 (13.6) | 0.243 | 1.158 (0.981–1.367) | | Overdominant | | | | | | GG + TT | 15 (88.2) | 14 (63.6) | — | 1.000 | | GT | 2 (11.8) | 8 (36.4) | 0.140 | 0.233 (0.042–1.293) |
| | Male | Allele | | | | | | G | 117 (81.3) | 88 (80.0) | — | 1.000 | | T | 27 (18.7) | 22 (20.0) | 0.873 | 0.923 (0.493–1.728) | | Codominant | | | | | | GG | 47 (65.3) | 36 (65.5) | — | 1.000 | | GT | 23 (31.9) | 16 (29.1) | 0.846 | 1.101 (0.509–2.382) | | TT | 2 (2.8) | 3 (5.4) | 0.652 | 0.511 (0.081–3.219) | | Dominant | | | | | | GG | 47 (65.3) | 36 (65.5) | — | 1.000 | | GT + TT | 25 (34.7) | 19 (34.5) | 1.000 | 1.008 (0.482–2.108) | | Recessive | | | | | | GG + GT | 70 (97.2) | 52 (94.5) | — | 1.000 | | TT | 2 (2.8) | 3 (6.5) | 0.652 | 0.495 (0.080–3.071) | | Overdominant | | | | | | GG + TT | 49 (68.1) | 39 (70.9) | — | 1.000 | | GT | 23 (31.9) | 16 (29.1) | 0.846 | 1.144 (0.533–2.457) |
| | Female | Allele | | | | | | G | 65 (85.5) | 77 (77.0) | — | 1.000 | | T | 11 (14.5) | 23 (230) | 0.180 | 0.567 (0.257–1.249) | | Codominant | | | | | | GG | 28 (73.7) | 31 (62.0) | — | 1.000 | | GT | 9 (23.7) | 15 (30.0) | 0.471 | 0.664 (0.251–1.755) | | TT | 1 (2.6) | 4 (8.0) | 0.366 | 0.277 (0.029–2.626) | | Dominant | | | | | | GG | 28 (73.7) | 31 (62.0) | — | 1.000 | | GT + TT | 10 (26.3) | 19 (38.0) | 0.264 | 0.583 (0.232–1.463) | | Recessive | | | | | | GG + GT | 37 (97.4) | 46 (92.0) | — | 1.000 | | TT | 1 (2.6) | 4 (8.0) | 0.384 | 0.311 (0.033–2.901) | | Overdominant | | | | | | GG + TT | 29 (76.3) | 35 (70.0) | — | 1.000 | | GT | 9 (23.4) | 15 (30.0) | 0.631 | 0.724 (0.277–1.895) |
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OR, odds ratios; CI, confidential intervals. Bold, significant results.
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