Rs4846049 Polymorphism at the 3′-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia
Table 3
Association of rs4846049 polymorphism with clinical features of ALL patients.
GG (n = 75)
GT (n = 32)
TT (n = 3)
value
Male (n, %)
47 (62.7)
23 (71.9)
2 (66.7)
0.723
Age (mean)
5.60 ± 3.31
4.63 ± 2.89
6.33 ± 1.16
0.301
Patients with age >8 years (n, %)
15 (20.0)
2 (6.3)
0 (0.0)
0.163
WBC (×109/L)
33.37 ± 78.92
28.40 ± 54.90
40.49 ± 65.31
0.929
Hb (g/L)
89.24 ± 19.68
87.91 ± 27.73
96.33 ± 29.01
0.818
Platelet (×109/L)
115.35 ± 113.98
112.00 ± 107.67
113.00 ± 41.62
0.990
Organomegaly (n, %)
50 (66.7)
21 (65.6)
3 (100.0)
0.715
Immunophenotype
0.436
T (n, %)
9 (12.0)
3 (9.4)
1 (33.3)
0.455
B (n, %)
65 (86.7)
28 (87.5)
2 (66.7)
0.501
Mixture (n, %)
1 (1.3)
1 (3.1)
0 (0.0)
0.537
FISH detection
C-myc break (n, %)
0 (0.00)
1 (3.1)
1 (33.3)
0.017
MLL break (n, %)
4 (5.3)
2 (6.3)
0 (0.0)
1.000
TCF3/PBX1fusion (n, %)
5 (6.7)
2 (6.3)
0 (0.0)
1.000
TEL-AML1fusion (n, %)
13 (17.3)
7 (2.2)
0 (0.0)
0.708
BCR, ABL1, ASS2 tricolour fusion (n, %)
3 (4.0)
0 (0.0)
0 (0.0)
0.589
Chromosome deficiency (n, %)
1 (1.3)
0 (0.0)
0 (0.0)
1.000
Normal (n, %)
48 (64.0)
20 (6.3)
2 (66.7)
1.000
Not done (n, %)
1 (1.3)
0 (0.0)
0 (0.0)
1.000
Karyotype changes
Normal (n, %)
29 (38.7)
13 (40.6)
3 (100.0)
0.132
Abnormal (n, %)
42 (56.0)
13 (40.6)
0 (0.0)
0.023
Not done (n, %)
4 (5.3)
6 (18.8)
0 (0.0)
0.096
WHO classification
0.936
B-ALL, recurrent cytogenetic abnormalities (n, %)
26 (34.7)
14 (43.8)
2 (66.7)
0.336
B-ALL, t (9; 22) (q34.1; q11.2); BCR-ABL1 (n, %)
3 (4.0)
0 (0.0)
0 (0.0)
0.589
B-ALL, t (v;11q23.3); KMT2A rearrangement (n, %)
3 (4.0)
2 (6.2)
0 (0.0)
0.682
B-ALL, t (12; 21) (p13.2; q22.1); ETV6-RUNX1 (n, %)
13 (17.3)
6 (18.8)
0 (0.0)
1.000
B-ALL, high hyperdiploid (n, %)
16 (21.3)
5 (15.6)
0 (0.0)
0.884
B-ALL, t (1; 19) (q23; p13.3); TCF3-PBX1 (n, %)
6 (8.0)
2 (6.2)
0 (0.0)
1.000
T-ALL (n, %)
8 (10.7)
3 (9.4)
1 (33.33)
1.000
FAB classification
L1 (n, %)
7 (9.3)
4 (12.5)
0 (0.0)
0.804
L2 (n, %)
51 (68.0)
21 (65.6)
2 (66.7)
0.921
L3 (n, %)
6 (8.0)
4 (12.5)
1 (33.3)
0.205
Unknown (n, %)
11 (14.7)
3 (9.4)
0 (0.0)
0.700
Lymphadenopathy (n, %)
55 (73.3)
22 (68.8)
2 (66.7)
0.843
CSF involvement (n, %)
0 (0.0)
1 (3.1)
0 (0.0)
0.318
WBC, white blood cell; Hb, hemoglobin; FAB, French-American-British; CSF, cerebrospinal fluid; FISH, fluorescence in situ hybridization. Bold, significant result at . One-sided value; the other were two-sided.
