Research Article
In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders
Table 1
Effect of Manilkara zapota extracts: chloroform (Mz.CHCl3), aqueous (Mz.Aq), and loperamide against castor oil-induced diarrhea (10 mL/kg) in mice.
| Treatment | No. of mice (out of 5) with diarrhea | Protection (%) |
| Saline (10 mL/kg) + castor oil | 5/5 | 0 | Mz.CHCl3 (50 mg/kg) + castor oil | 2/5 | 60 | Mz.CHCl3 (100 mg/kg) + castor oil | 1/5 | 80 | Mz.CHCl3 (300 mg/kg) + castor oil | 0/5 | 100 | Mz. Aq (50 mg/kg) + castor oil | 4/5 | 20 | Mz.Aq (100 mg/kg) + castor oil | 3/5 | 40 | Mz. Aq (300 mg/kg) + castor oil | 2/5 | 60 | Loperamide (10 mg/kg) + castor oil | 0/5 | 100 |
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and versus saline + castor oil-treated group ( Χ2-test). |