Antiplasmodial Activity Assay of 3-Chloro-4-(4-chlorophenoxy) Aniline Combinations with Artesunate or Chloroquine In Vitro and in a Mouse Model

Table 2

In vitro IC₅₀ values of AS, CQ, and ANI against Plasmodium isolates.

Drug	CQ sensitive (3D7)	CQ resistant (W2)
	IC50 ± SD	IC50 ± SD
ANI	7.12 ± 0.17 μg/ml	8.75 ± 0.3 μg/ml
CQ	10.9 ± 1.1 ng/ml	48 ± 0.07 ng/ml
AS	1.6 ± 0.05 ng/ml	2.4 ± 0.1 ng/ml

ANI had lower in vitro antiplasmodial activity compared to AS and CQ with its values in μg/ml.