Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
Figure 5
Effects of A. fragrantissima on the heart tissue histopathological changes detected by H & E staining in Adr-induced cardiotoxicity in rat (low power magnification ×200). Photo (a) represents control group, cardiac muscle showing branching, anastomosing, and striated muscle fibers with central oval vesicular nuclei (▸) and acidophilic cytoplasm. Notice the interstitial blood capillaries (→) and spindle-shaped connective tissue cells (thick arrow). Photo (b) represents A. fragrantissima 800 group. Photo (c) represents Adr group, cardiac muscle showing pale cytoplasm with pyknotic nuclei (thick arrows). Focal areas of widely separated cardiac muscle fibers ranging from degenerated cytoplasm up to necrosis. Photo (d) represents Adr group, cardiac muscle showing the perivascular edema around a coronary blood vessel (thick arrows) together with marked disorganization of the thin degenerated fibers (). Notice the scattered pyknotic nuclei in the damaged fibers. Photo (e) represents A. fragrantissima 400 + Adr group, showing necrosis of focal areas of degenerated cardiac muscle fiber (thick arrows). Notice the dark small pyknotic nuclei of muscle fibers with abnormal staining (arrow head). Photo (f) represents A. fragrantissima 800 + Adr group, showing the control appearance of the branching, anastomosing, and striated cardiac muscle.