Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
Figure 6
Effects of A. fragrantissima on the heart tissue histopathological changes detected by H & E staining in control and Adr-induced cardiotoxicity in rat (high-power magnification ×400). Photo (a) represents the cardiac muscle of control group. Photo (b) represents the cardiac muscle of A. fragrantissima 800 group, showing nearly normal cardiac muscle. Photo (c) represents the cardiac muscle of Adr group, showing focal disruption of some fibers (→) with pale acidophilic sarcoplasm. Notice the marked focal aggregation of inflammatory mononuclear cells (), interstitial fibroblasts (arrow head), and edema in between the fibers. Photo (d) represents the cardiac muscle of A. fragrantissima 400 + Adr group, showing the widely separated degenerated myocardial fibers with pale homogenous cytoplasm (thick arrows). Notice focal cytoplasmic vacuolization of some cardiac muscle fibers (→). Photo (e) represents the cardiac muscle of A. fragrantissima 800 + Adr group, showing the normal branched appearance of the cardiac muscle fibers.