Bone Marrow-Derived Mesenchymal Stem Cell Potential Regression of Dysplasia Associating Experimental Liver Fibrosis in Albino Rats

Figure 5

(a–d) Light photomicrographs of rat liver sections stained by Gomori’s trichrome. (a) CG showing the average green fibers in the stroma of the portal tract (PT). No fibers are seen between hepatocytes. (b) LFG showing the prominent deposits of collagen fibers around the central veins (CV), in the portal tract (PT) and between hepatocytes (arrow). (c) MSCs + CCl₄G showing the fine collagen fiber deposits around the central veins (CV) and between the hepatic cords (arrow). (d) MSCsG showing the minimal deposits of collagen fibers in the portal tracts (PT) of hepatic lobules (mic. mag.: 200×). (e) A morphometric study for the area percentage of collagen. Values represent mean ± SD. Different letters indicate significant statistical differences at . ^aSignificant compared with CG1. ^bSignificant compared with CG2. ^cSignificant compared with CG3. ^dSignificant compared with CG4. ^eSignificant compared with LFG. ^fSignificant compared with MSCs + CCl₄G. It revealed that CCl₄ treatment led to significant increase in mean area percentage of collagen which was reduced following the BM-MSCs treatment.

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