Enterococci: Between Emerging Pathogens and Potential Probiotics

Table 1

Classification of enterocins [73].

Class	Sub-class	Sub-group/ Characteristic	Examples
Class I	Lantibiotic enterocins	Heamolytic bacteriocins; Formed by two peptides cylLs and cylLL; Their action needs the presence of the two peptides	Cytolisin
Class II, small nonlantibiotic peptides	II.1 possesses a cationic and hydrophile region with consensus sequence YGNGV in the N-terminal extremity and a disulphide bridge formed by two cysteins in the N-terminal extremity	Sub-group 1  possessesan ABC transporter for the secretion of enterocins	Enterocin A,; Enterocin CRL35
		Sub-group 2 The production is realised via a mature pre-protein	Enterocin P, Enterocin SEK4, Bacteriocin 31, Bacteriocin T8
	II.2 synthesised without leader peptide, did not possess the consensus sequence, nor the system of secretion ABC transporter	Sub-group 1 Monomeric proteins	Enterocin RJ-11, Enterocin Q, Enterocin EJ97
		Sub-group 2  Need for the formation of an heterodimeric complex	Enterocin L50, Enterocin MR10
	II.3	Linear enterocins with leader peptide	Enterocin B, Bacteriocin 32 Enterocins1071 A and B
Class III, cyclic enterocins		Cyclic peptides	Enterocin AS-48 Enterocin AS-48 RJ
Class IV, proteins of high molecular weight		Peptides of high molecular weight (34.5 kDa) and heat-labiles	Enterolysin A