Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2<i>α</i> and miR-494

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Cell line</td><td class="align_center" colspan="2"><sup>a</sup>IC<sub>50</sub></td></tr><tr class="thead"><td class="align_center">EESP (mg/mL)</td><td class="align_center">5-FU (mM)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">HCT-8</td><td class="align_center">0.77 ± 0.07</td><td class="align_center">0.60 ± 0.13</td></tr><tr><td class="align_left">HCT-8/5-FU</td><td class="align_center">0.75 ± 0.09</td><td class="align_center">154.46 ± 14.07</td></tr><tr><td class="align_left">RI</td><td class="align_center">1.03</td><td class="align_center">257.40</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div><sup>a</sup>IC<sub>50</sub> represents semi-inhibitory concentration of modulators.<br/></div></td></tr></table>

<div>Inhibitory effects of EESP and 5-FU on HCT-8 and HCT-8/5-FU cells for 48 h (<i>n</i> = 3).</div>

BioMed Research International

tab1

Table 1

Table 1: Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2<i>α</i> and miR-494 

Table 1 | Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494 