MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy

Table 2

The beneficial effect of MSCs exosomes for PNI.

Cell source	Exosomal cargo	Effect	The activation of signaling pathway	Reference
hAMSCs	/	Against neuron damage induced by glutamate	the PI3K/Akt signaling pathway	[94]
Gingiva-derived MSCs	/	Promote peripheral nerve regeneration	c-JUN pathway governed repair phenotype of Schwann cells	[95]
rBMMSCs	miR-17-92 cluster	Increase neural plasticity and functional recovery and promote Axonal Growth of Cortical Neurons	the PI3K/protein kinase B/mechanistic target of rapamycin /glycogen synthase kinase 3β, or the PTEN/mTOR signaling pathway	[105, 106]
	miR-133b	Improve neural plasticity and functional recovery	/	[107]
rADSCs	PEDF	Ameliorate cerebral I/R injury	Autophagy and apoptotic pathway	[108]
	Multiple factors	Increase neurite outgrowth in vitro and enhance regeneration	/
Umbilical cord MSCs	let-7b	Alleviate inflammatory reaction by promoting M2 macrophage activation	The signal axis by TLR 4 / NF-κB / STAT-3 / AKT	[122]
rADSCs	miR-30d-5p	Prevent cerebral injury by mediating microglial polarization to M1	Autophagy pathway	[123]
rBMMSCs	/	Enhance neurite remodeling, endogenous angiogenesis, and neurogenesis and reduce inflammation	/	[129, 130]

“/”: not mentioned in the original article; ADSCs: adipose derived mesenchymal stem cells; BMMSCs: bone marrow derived stem cells.