Review Article
MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy
Table 2
The beneficial effect of MSCs exosomes for PNI.
| Cell source | Exosomal cargo | Effect | The activation of signaling pathway | Reference |
| hAMSCs | / | Against neuron damage induced by glutamate | the PI3K/Akt signaling pathway | [94] | Gingiva-derived MSCs | / | Promote peripheral nerve regeneration | c-JUN pathway governed repair phenotype of Schwann cells | [95] | rBMMSCs | miR-17-92 cluster | Increase neural plasticity and functional recovery and promote Axonal Growth of Cortical Neurons | the PI3K/protein kinase B/mechanistic target of rapamycin /glycogen synthase kinase 3β, or the PTEN/mTOR signaling pathway | [105, 106] | miR-133b | Improve neural plasticity and functional recovery | / | [107] | rADSCs | PEDF | Ameliorate cerebral I/R injury | Autophagy and apoptotic pathway | [108] | Multiple factors | Increase neurite outgrowth in vitro and enhance regeneration | / | | Umbilical cord MSCs | let-7b | Alleviate inflammatory reaction by promoting M2 macrophage activation | The signal axis by TLR 4 / NF-κB / STAT-3 / AKT | [122] | rADSCs | miR-30d-5p | Prevent cerebral injury by mediating microglial polarization to M1 | Autophagy pathway | [123] | rBMMSCs | / | Enhance neurite remodeling, endogenous angiogenesis, and neurogenesis and reduce inflammation | / | [129, 130] |
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“/”: not mentioned in the original article; ADSCs: adipose derived mesenchymal stem cells; BMMSCs: bone marrow derived stem cells.
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