Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition

Figure 3

Effect of TXL on EndMT of the MF in vivo. (a) Effects of TXL on protein expression of endothelial markers (CD31 and VE-cadherin) and mesenchymal markers (α-SMA and FSP-1) in the MF were determined by Western blotting analysis. (a1)–(a4) showed corresponding column chart. n=3, P<0.01 vs. control group; ^#P<0.05 ^##P<0.01 vs. Model group; ^&P <0.05 ^&&P <0.01 vs. benazepril group. (b) Effects of TXL on expression of CD31, VE-cadherin, α-SMA, and FSP-1 at mRNA levels were analyzed by qRT-PCR. (b1)–(b4) showed corresponding column chart. n=4, P<0.05 or P<0.01 vs. control group; ^##P<0.01 vs. Model group; ^&P <0.05 ^&&P <0.01 vs. benazepril group.

(a)

(b)