Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition

<p><i>NRG-1/ErbB-PI3K/AKT signaling pathway was activated by TXL</i>. Effects of TXL on protein expression of NRG-1, p-ErbB2, p-ErbB4, p-AKT, and snail in vitro were determined by Western blotting analysis. (a1)–(a6) showed corresponding column chart. <i>β</i>-actin expressions served as internal control. n=3, <svg height="6.01072pt" id="M10" style="vertical-align:-0.04980993pt" version="1.1" viewbox="-0.0498162 -5.96091 15.4189 6.01072" width="15.4189pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.631,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z"></path></g></svg>P&lt;0.01 vs. control group;<sup> #</sup> P&lt;0.05 <sup>##</sup> P&lt;0.01 vs. hypoxia group; <svg height="11.7737pt" id="M11" style="vertical-align:-0.04990005pt" version="1.1" viewbox="-0.0498162 -11.7238 9.27122 11.7737" width="9.27122pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,2.179,-5.741)"><path d="M717 427H488V399C559 390 569 378 549 331C530 287 513 253 489 216C425 282 354 343 321 371C360 397 383 416 402 432C423 450 444 479 444 520C444 600 377 658 296 658C208 658 132 590 132 500C132 446 159 403 204 361C119 300 54 260 54 167C54 80 125 -14 251 -14C323 -14 389 22 461 118C494 84 536 37 548 23C560 10 615 -13 670 -18L677 -9C647 49 556 150 514 191C549 244 573 285 601 324C634 373 647 391 717 399V427ZM285 624C335 624 369 576 369 519C369 465 342 426 295 391C235 437 204 472 204 524C204 584 239 624 285 624ZM278 54C212 54 139 100 139 196C139 245 164 292 230 339C321 265 385 204 438 145C405 99 345 54 278 54Z"></path></g></svg> P&lt;0.05<svg height="11.7737pt" id="M12" style="vertical-align:-0.04990005pt" version="1.1" viewbox="-0.0498162 -11.7238 15.7656 11.7737" width="15.7656pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,2.179,-5.741)"><path d="M717 427H488V399C559 390 569 378 549 331C530 287 513 253 489 216C425 282 354 343 321 371C360 397 383 416 402 432C423 450 444 479 444 520C444 600 377 658 296 658C208 658 132 590 132 500C132 446 159 403 204 361C119 300 54 260 54 167C54 80 125 -14 251 -14C323 -14 389 22 461 118C494 84 536 37 548 23C560 10 615 -13 670 -18L677 -9C647 49 556 150 514 191C549 244 573 285 601 324C634 373 647 391 717 399V427ZM285 624C335 624 369 576 369 519C369 465 342 426 295 391C235 437 204 472 204 524C204 584 239 624 285 624ZM278 54C212 54 139 100 139 196C139 245 164 292 230 339C321 265 385 204 438 145C405 99 345 54 278 54Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.649,-5.741)"><path d="M717 427H488V399C559 390 569 378 549 331C530 287 513 253 489 216C425 282 354 343 321 371C360 397 383 416 402 432C423 450 444 479 444 520C444 600 377 658 296 658C208 658 132 590 132 500C132 446 159 403 204 361C119 300 54 260 54 167C54 80 125 -14 251 -14C323 -14 389 22 461 118C494 84 536 37 548 23C560 10 615 -13 670 -18L677 -9C647 49 556 150 514 191C549 244 573 285 601 324C634 373 647 391 717 399V427ZM285 624C335 624 369 576 369 519C369 465 342 426 295 391C235 437 204 472 204 524C204 584 239 624 285 624ZM278 54C212 54 139 100 139 196C139 245 164 292 230 339C321 265 385 204 438 145C405 99 345 54 278 54Z"></path></g></svg> P&lt;0.01 vs. hypoxia +NRG-1 siRNA group; <sup>+</sup> P&lt;0.05 <sup>++</sup> P&lt;0.01 vs. hypoxia +TXL group.</p>

BioMed Research International

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Figure 5

Figure 5: Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition 

Figure 5 | Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition 