Study Place Mean age (years) Study design Number of eyes (number of patients) Gender (female/male) OCTA device Macular scan size Foveal and parafoveal VD: inner; outer diameter (mm) Outcomes of the VD assessed by OCTA Quality score Sugahara et al. [12 ] Japan 49.9 ± 17.6 54.4 ± 19.9 Cross-sectional study Cases: 68 (68) Controls: 32 (32) 36/32 20/12 Optovue 3 1; 1–2.5 FAZ-S, FAZ-D, PSVD, PDVD Toto et al. [13 ] Italy 40.1 ± 7.3 42.2 ± 6.5 Cross-sectional study Cases: 26 (14) Controls: 24 (24) 6/8 10/14 Optovue 6 1; 1–2.5 FT, FSVD, FDVD, PSVD, PDVD, WCVD Koyanagi et al. [14 ] Japan 42.1 ± 25.7 41.2 ± 42.5 Cross-sectional study Cases: 73 (73) Controls: 36 (36) 36/37 20/16 Optovue 3 1; 1–2.5 FAZ-S, FAZ-D, FSVD, FDVD, PSVD, PDVD Parodi et al. [15 ] Italy 53 ± 18 53 ± 17 Cross-sectional study Cases: 32 (16) Controls: 30 (30) 6/10 16/14 Topcon 3 None FAZ-S, FAZ-D, FSVD, FDVD, WCVD Wang et al. [22 ] China 38.7 ± 10.5 42.3 ± 15.7 Prospective case-control study Cases: 40 (20) Controls: 26 (13) 9/11 8/5 Zeiss 6 1; 1–2.5 FT, FAZ Alnawaiseh et al. [23 ] Germany 42.40 ± 14.11 41.47 ± 13.54 Prospective case-control study Cases: 20 (20) Controls: 21 (21) 11/9 12/9 Optovue 6 1; 1–2.5 FAZ-S, FAZ-D, FSVD, FDVD, PSVD, PDVD, WCVD Takagi et al. [24 ] Japan 46.8 ± 12.6 50.3 ± 10.0 Case-control study Cases: 50 (32) Controls: 22 (12) 18/14 11/3 Optovue 3 None FAZ-S, FAZ-D
FT = Foveal thickness, FAZ-S = Foveal avascular zone superficial, FAZ-D = Foveal avascular zone deep, FSVD = Foveal superficial vessel density, FDVD = Foveal deep vessel density, PSVD = Parafoveal superficial vessel density, PDVD = Parafoveal deep vessel density, WCVD = Whole choriocapillaris vessel density.