Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

Table 1

Clinical characteristics of the included studies.

Study	Place	Mean age (years)	Study design	Number of eyes (number of patients)	Gender (female/male)	OCTA device	Macular scan size	Foveal and parafoveal VD: inner; outer diameter (mm)	Outcomes of the VD assessed by OCTA	Quality score
Sugahara et al. [12]	Japan	49.9 ± 17.6; 54.4 ± 19.9	Cross-sectional study	Cases: 68 (68); Controls: 32 (32)	36/32; 20/12	Optovue	3	1; 1–2.5	FAZ-S, FAZ-D, PSVD, PDVD
Toto et al. [13]	Italy	40.1 ± 7.3; 42.2 ± 6.5	Cross-sectional study	Cases: 26 (14); Controls: 24 (24)	6/8; 10/14	Optovue	6	1; 1–2.5	FT, FSVD, FDVD, PSVD, PDVD, WCVD
Koyanagi et al. [14]	Japan	42.1 ± 25.7; 41.2 ± 42.5	Cross-sectional study	Cases: 73 (73); Controls: 36 (36)	36/37; 20/16	Optovue	3	1; 1–2.5	FAZ-S, FAZ-D, FSVD, FDVD, PSVD, PDVD
Parodi et al. [15]	Italy	53 ± 18; 53 ± 17	Cross-sectional study	Cases: 32 (16); Controls: 30 (30)	6/10; 16/14	Topcon	3	None	FAZ-S, FAZ-D, FSVD, FDVD, WCVD
Wang et al. [22]	China	38.7 ± 10.5; 42.3 ± 15.7	Prospective case-control study	Cases: 40 (20); Controls: 26 (13)	9/11; 8/5	Zeiss	6	1; 1–2.5	FT, FAZ
Alnawaiseh et al. [23]	Germany	42.40 ± 14.11; 41.47 ± 13.54	Prospective case-control study	Cases: 20 (20); Controls: 21 (21)	11/9; 12/9	Optovue	6	1; 1–2.5	FAZ-S, FAZ-D, FSVD, FDVD, PSVD, PDVD, WCVD
Takagi et al. [24]	Japan	46.8 ± 12.6; 50.3 ± 10.0	Case-control study	Cases: 50 (32); Controls: 22 (12)	18/14; 11/3	Optovue	3	None	FAZ-S, FAZ-D

FT = Foveal thickness, FAZ-S = Foveal avascular zone superficial, FAZ-D = Foveal avascular zone deep, FSVD = Foveal superficial vessel density, FDVD = Foveal deep vessel density, PSVD = Parafoveal superficial vessel density, PDVD = Parafoveal deep vessel density, WCVD = Whole choriocapillaris vessel density.