Research Article
Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway
Figure 8
Inhibition of the EGFR/MAPK pathway after compound 1 treatment in MDA-MB-231 and MCF-7 cells. MDA-MB-231 and MCF-7 cells were incubated with compound 1 at IC0 and IC50 for 4 hours, and human recombinant EGF (hrEGF) was used as a positive control. Bar graphs of fluorescence intensity of EGFR and MAPK in MDA-MB-231 cells (a) and MCF-7 cells (b) were compared with the control (as folds) shown by using Guava® Flow Cytometry easyCyte™ Systems. The statistical significance values compared to the control (without treatment) are marked with asterisks, .
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