Myoferlin, a Membrane Protein with Emerging Oncogenic Roles

Figure 1

Schematic structure of MYOF. MYOF has seven C2 domains, a Ferlin A domain, a DysF domain as well as a single C-terminal transmembrane helix. C2-domains are responsible for Ca²⁺-dependent lipid binding and interacting with targeting proteins. FerA binds to phospholipids in a Ca²⁺ independent manner. DysF is possibly responsible for receptor-mediated endocytosis.