Myoferlin, a Membrane Protein with Emerging Oncogenic Roles

Figure 4

The role of MYOF in IL-6R related pathway. Activity of MYOF is inhibited by EDH2 on cell membrane. Upon stimulation by IL-6, IL-6R phosphorylates STAT3, which interacts with MYOF and translocates to the nucleus. Phosphorylated STAT3 activates its target gene expression and promotes tumor progression.